JAMA internal medicine
-
JAMA internal medicine · May 2015
Randomized Controlled Trial Multicenter StudyPrimary Results of the Patient-Centered Disease Management (PCDM) for Heart Failure Study: A Randomized Clinical Trial.
Heart failure (HF) has a major effect on patients' health status, including their symptom burden, functional status, and health-related quality of life. ⋯ This multisite randomized trial of a multifaceted HF PCDM intervention did not demonstrate improved patient health status compared with usual care.
-
JAMA internal medicine · May 2015
Randomized Controlled Trial Multicenter StudySafety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial.
For patients with limited prognosis, some medication risks may outweigh the benefits, particularly when benefits take years to accrue; statins are one example. Data are lacking regarding the risks and benefits of discontinuing statin therapy for patients with limited life expectancy. ⋯ This pragmatic trial suggests that stopping statin medication therapy is safe and may be associated with benefits including improved QOL, use of fewer nonstatin medications, and a corresponding reduction in medication costs. Thoughtful patient-provider discussions regarding the uncertain benefit and potential decrement in QOL associated with statin continuation in this setting are warranted.
-
JAMA internal medicine · May 2015
Randomized Controlled Trial Multicenter StudyA targeted infection prevention intervention in nursing home residents with indwelling devices: a randomized clinical trial.
Indwelling devices (eg, urinary catheters and feeding tubes) are often used in nursing homes (NHs). Inadequate care of residents with these devices contributes to high rates of multidrug-resistant organisms (MDROs) and device-related infections in NHs. ⋯ Our multimodal TIP intervention reduced the overall MDRO prevalence density, new methicillin-resistant S aureus acquisitions, and clinically defined catheter-associated urinary tract infection rates in high-risk NH residents with indwelling devices. Further studies are needed to evaluate the cost-effectiveness of this approach as well as its effects on the reduction of MDRO transmission to other residents, on the environment, and on referring hospitals.