JAMA internal medicine
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JAMA internal medicine · Jun 2016
Randomized Controlled Trial Multicenter StudyEffect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial.
Calorie restriction (CR) increases longevity in many species and reduces risk factors for chronic diseases. In humans, CR may improve health span, yet concerns remain about potential negative effects of CR. ⋯ In nonobese adults, CR had some positive effects and no negative effects on health-related QOL.