JAMA neurology
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Multicenter Study Observational Study
Factors associated with the onset and persistence of post-lumbar puncture headache.
This study assesses factors associated with the most common adverse event following lumbar puncture. ⋯ Factors that acutely lower CSF pressure (eg, seated positioning or extracting very high volumes of CSF) may be associated with transient post-lumbar puncture headache, without increasing rates of persistent PDPH or therapeutic blood patch. Collection of up to 30 mL of CSF appears to be well tolerated and safe.