JAMA pediatrics
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Review Meta Analysis
Oxygen saturation target range for extremely preterm infants: a systematic review and meta-analysis.
The optimal oxygen saturation (SpO2) target for extremely preterm infants is unknown. ⋯ Although infants cared for with a liberal oxygen target had significantly lower mortality before hospital discharge than infants cared for with a restricted oxygen target, the quality of evidence for this estimate of effect is low. Necrotizing enterocolitis occurred less frequently in the liberal oxygen group. We found no significant differences in death or disability at 24 months, bronchopulmonary dysplasia, retinopathy of prematurity, neurodevelopmental outcomes, or hearing loss at 24 months.