JAMA psychiatry
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Randomized Controlled Trial Multicenter Study
Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial.
No highly effective interventions to prevent delirium have been identified. ⋯ Ramelteon administered nightly to elderly patients admitted for acute care may provide protection against delirium. This finding supports a possible pathogenic role of melatonin neurotransmission in delirium.