JAMA psychiatry
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Randomized Controlled Trial
Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial.
Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational data suggesting lower rates of depression in individuals treated with aspirin. There currently appears to be no evidence-based pharmacotherapies for the primary prevention of depression. ⋯ Low-dose aspirin did not prevent depression in this large-scale study of otherwise healthy older adults.