Urolithiasis
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Meta Analysis
Nephrolithiasis as a risk factor of chronic kidney disease: a meta-analysis of cohort studies with 4,770,691 participants.
The objective of the study was to investigate the association between nephrolithiasis and the risk of chronic kidney disease (CKD). PubMed, Embase and ScienceDirect databases were searched for relevant cohort studies. A meta-analysis was conducted by pooling data from these studies via an inverse variance method. ⋯ Publication bias was not detected. Sensitivity analysis indicated that the results were stable. Nephrolithiasis may increase the risk of CKD, regardless of the patient population (region), and may be an important risk factor for end-stage kidney disease.