Cellular immunology
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Cellular immunology · May 2021
A transgene-encoded truncated human epidermal growth factor receptor for depletion of anti- B-cell maturation antigen CAR-T cells.
Chimeric antigen receptor T cells (CAR-T) against B-cell maturation antigen (BCMA) has been used to treat multiple myeloma (MM). CAR-T cells co-expressing a truncated human EGFR (tEGFR) has been proposed for in vivo cell ablation. ⋯ We confirm that BCMA is a suitable target for CAR- T cells and tEGFR is a effective tool for cellular ablation.