European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Oct 2010
Randomized Controlled TrialOxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir.
this study aimed to investigate the effect of antivirals ritonavir and lopinavir/ritonavir on the pharmacokinetics and pharmacodynamics of oral oxycodone, a widely used opioid receptor agonist used in the treatment of moderate to severe pain. ⋯ ritonavir and lopinavir/ritonavir greatly increase the plasma concentrations of oral oxycodone in healthy volunteers and enhance its effect. When oxycodone is used clinically in patients during ritonavir and lopinavir/ritonavir treatment, reductions in oxycodone dose may be needed to avoid opioid-related adverse effects.