European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Jun 2012
Meta AnalysisThe adverse event profile of pregabalin across different disorders: a meta-analysis.
In a recent meta-analysis of 38 double-blind randomized controlled trials (RCTs) comparing pregabalin (PGB) to placebo, we found 20 adverse events (AEs) to be significantly associated with PGB treatment. In the present study, we evaluated whether the incidence of these 20 AEs differs across distinct disorders in which PGB was investigated. ⋯ Although drug-resistant partial epilepsy is associated with a higher probability of developing vestibulo-cerebellar AEs, the risk for PGB toxicity does not differ across distinct disorders.