The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Nov 1996
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialAcute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group.
Leukotrienes produced by the 5-lipoxygenase pathway of arachidonic acid metabolism may mediate bronchoconstriction and inflammatory changes important in the pathophysiology of asthma. Leukotriene inhibition may be effective in asthma management. ⋯ Zileuton produces objective and subjective improvements in patients with mild to moderate asthma and is well tolerated.