The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Feb 2010
Multicenter Study Meta AnalysisA genome-wide association study on African-ancestry populations for asthma.
Asthma is a complex disease characterized by striking ethnic disparities not explained entirely by environmental, social, cultural, or economic factors. Of the limited genetic studies performed on populations of African descent, notable differences in susceptibility allele frequencies have been observed. ⋯ This study illustrates the complexity of identifying true associations for a complex and heterogeneous disease, such as asthma, in admixed populations, especially populations of African descent.