The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Aug 2014
Randomized Controlled TrialEffects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma.
Prostaglandins that constrict and relax airways are synthesized in reactions catalyzed by either COX-1 or COX-2. It is not known whether selective inhibition of COX-2 makes asthmatic responses better or worse. ⋯ This first study of COX-2 inhibition in provoked asthma found no negative effects of etoricoxib on allergen-induced airflow obstruction and sputum eosinophils, basal lung function, or methacholine responsiveness. The study suggests that short-term use of COX-2 inhibitors is safe in subjects with asthma.