The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Feb 2017
Meta AnalysisGenome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A.
Although a striking proportion (25% to 45%) of patients with chronic obstructive pulmonary disease are never-smokers, most genetic susceptibility studies have not focused on this group exclusively. ⋯ The genes HHIP and FAM13A confer a risk for airway obstruction in general that is not driven exclusively by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease.