The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · May 2018
Randomized Controlled TrialEnhanced plasmacytoid dendritic cell antiviral responses after omalizumab.
Atopy and viral respiratory tract infections synergistically promote asthma exacerbations. IgE cross-linking inhibits critical virus-induced IFN-α responses of plasmacytoid dendritic cells (pDCs), which can be deficient in patients with allergic asthma. ⋯ These findings indicate that omalizumab treatment augments pDC IFN-α responses and attenuates pDC FcεRIα protein expression and provide evidence that these effects are related. These results support a potential mechanism underlying clinical observations that allergic sensitization is associated with increased susceptibility to virus-induced asthma exacerbations.