Anesthesiology
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Editorial Comment Comparative Study
Obstetric anesthesia: what have you done for us lately?
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Randomized Controlled Trial Multicenter Study Clinical Trial
Effect of mivazerol on perioperative cardiac complications during non-cardiac surgery in patients with coronary heart disease: the European Mivazerol Trial (EMIT).
Mivazerol is a drug with alpha2-agonist properties that reduces post-ganglionic noradrenaline availability and spinal efferent sympathetic output. ⋯ The alpha2-adrenergic agonist, mivazerol, did not alter the rates of myocardial infarction or cardiac death in patients with known coronary heart disease undergoing noncardiac surgery. However, it may have protected patients undergoing vascular surgery from further coronary events, and a specific study of such patients is now indicated.
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomized trial of hypotensive epidural anesthesia in older adults.
Data are sparse on the incidence of postoperative cognitive, cardiac, and renal complications after deliberate hypotensive anesthesia in elderly patients. ⋯ Elderly patients can safely receive controlled hypotensive epidural anesthesia with this protocol. There was no evidence of greater risks, or early benefits, with the use of the more markedly hypotensive range.
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Xenon is a noble gas with anesthetic properties currently under investigation for use in humans. This study was performed to evaluate whether xenon may trigger malignant hyperthermia in susceptible swine. ⋯ The authors conclude that xenon does not trigger malignant hyperthermia in susceptible swine.