Anesthesiology
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Randomized Controlled Trial Comparative Study Clinical Trial
Low- and medium-molecular-weight hydroxyethyl starches: comparison of their effect on blood coagulation.
High-molecular-weight hydroxyethyl starch (HES) compromises blood coagulation more than medium-molecular-weight HES. The authors compared medium molecular weight HES (200 kd [HES200]) and low-molecular-weight HES (70 kd [HES70]). ⋯ Low-molecular-weight hydroxyethyl starch (70 kd) compromises blood coagulation slightly less than HES200, but it is unclear whether this is clinically relevant.
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Randomized Controlled Trial Comparative Study Clinical Trial
Acid-base changes caused by 5% albumin versus 6% hydroxyethyl starch solution in patients undergoing acute normovolemic hemodilution: a randomized prospective study.
Preoperative acute normovolemic hemodilution (ANH) is an excellent model for evaluating the effects of different colloid solutions that are free of bicarbonate but have large chloride concentrations on acid-base equilibrium. ⋯ ANH with 5% albumin or 6% hydroxyethyl starch solutions led to metabolic acidosis. A dilution of extracellular bicarbonate or changes in strong ion difference and albumin concentration offer explanations for this type of acidosis.
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Randomized Controlled Trial Comparative Study Clinical Trial
Dilutional acidosis following hetastarch or albumin in healthy volunteers.
The intent of this study was to evaluate the impact of the commonly used colloids-hetastarch and albumin-on in vivo acid-base balance. From this evaluation, a better understanding of the mechanism of dilutional acidosis was expected. ⋯ Decreases in base excess were observed for 210 min after hetastarch administration but not after albumin. The mechanism for this difference is discussed.
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Pressure-time curve predicts minimally injurious ventilatory strategy in an isolated rat lung model.
We tested the hypothesis that the pressure-time (P-t) curve during constant flow ventilation can be used to set a noninjurious ventilatory strategy. ⋯ The predictive power of coefficient b to predict noninjurious ventilatory strategy in a model of acute lung injury is high.