Anesthesiology
-
Randomized Controlled Trial
Cognitive changes after saline or Plasmalyte infusion in healthy volunteers: a multiple blinded, randomized, cross-over trial.
In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann's (Ringer's lactate) solution. The authors tested the hypothesis that saline infusion would produce greater adverse cognitive changes than Plasmalyte infusion. ⋯ Despite expected differences in plasma chemistry, the authors found that measures of cognition did not differ after infusions of Plasmalyte or saline.