Anesthesiology
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The reduction of γ-aminobutyric acid (GABA) type A receptor-mediated inhibition has long been implicated in spinal sensitization of nociceptive responses. However, it is largely unknown which signaling cascades in spinal dorsal horn neurons are initiated by the reduced inhibition to trigger pain hypersensitivity. ⋯ These data identified STEP61 as a key intermediary for GABAergic inhibition to regulate pain sensitization.