Anesthesiology
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Multicenter Study Observational Study
Prolonged Catheter Use and Infection in Regional Anesthesia: A Retrospective Registry Analysis.
Prolonged catheter use is controversial because of the risk of catheter-related infection, but the extent to which the risk increases over time remains unknown. We thus assessed the time-dependence of catheter-related infection risk up to 15 days. ⋯ An online visual overview is available for this article at http://links.lww.com/ALN/B683.
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A recent U. S. Food and Drug Administration warning advised that prolonged or repeated exposure to general anesthetics may affect neurodevelopment in children. ⋯ In several studies, the amount of added risk is very small; however, there is some evidence for a greater association with multiple exposures. These results may be consistent with the preclinical data, but the possibility of confounding means the positive associations can only be regarded as weak evidence for causation. Finally, there is strong evidence that brief exposure is not associated with any long term risk in humans.