Anesthesiology
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Unfractionated heparin, administered during venoarterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depends on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent on extracorporeal membrane oxygenation; however, its association with acquired antithrombin deficiency is poorly understood. The objective of this study was to describe longitudinal changes in plasma antithrombin levels during extracorporeal membrane oxygenation support and evaluate the association between antithrombin levels and heparin responsiveness. The hypothesis was that extracorporeal membrane oxygenation support would be associated with acquired antithrombin deficiency and related decreased heparin responsiveness. ⋯ Venoarterial extracorporeal membrane oxygenation support was associated with a moderate acquired antithrombin deficiency, mainly during the first 72 h, that did not correlate with heparin responsiveness.
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Randomized Controlled Trial
Reversal of propofol-induced depression of the hypoxic ventilatory response by BK-channel blocker ENA-001: a randomized controlled trial.
The agnostic respiratory stimulant ENA-001 blocks carotid body BK-channels, reversing propofol's impairment of the hypoxic ventilatory response.
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