Clinical radiology
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Randomized Controlled Trial Clinical Trial
A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.
Forty patients who were suffering from radiation induced emesis were entered into a prospectively randomised double-blind cross-over study comparing nabilone with metoclopramide. Only patients who had at least five treatments remaining of their planned course of irradiation were randomised, in order to allow an adequate time to monitor the degree of symptom control and any adverse effects of the two drugs. Patient characteristics and the incidence and severity of nausea and vomiting were similar for the two groups. There was no difference in the efficacy of the two drugs but the incidence and severity of adverse reactions was significantly greater in those patients who received nabilone.
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An analysis of the plain film changes of the jaws in 51 histologically confirmed cases of Burkitt's lymphoma was carried out. In tumours confined clinically to the jaws there was a 91% incidence of effacement of the dental lamina dura while in tumours confined clinically to the abdomen there was an incidence of 72.7%. When tumour deposits were clinically present in more than one anatomical site, almost all cases showed effacement of the dental lamina dura. These findings emphasise the need for jaw radiographs to reinforce the diagnosis in suspected cases of Burkitt's lymphoma.