Seminars in arthritis and rheumatism
-
Semin. Arthritis Rheum. · Jun 2010
Randomized Controlled Trial Multicenter StudyLong-term safety, tolerability, and efficacy of duloxetine in the treatment of fibromyalgia.
To assess the long-term safety, tolerability, and efficacy of duloxetine in patients with fibromyalgia. ⋯ These findings support a positive risk/benefit profile for duloxetine in the long-term treatment of fibromyalgia.
-
Semin. Arthritis Rheum. · Jun 2010
ReviewSleep as a marker in the effective management of chronic osteoarthritis pain with opioid analgesics.
Sleep disturbances frequently accompany chronic pain from osteoarthritis (OA), and their effective management may reflect successful treatment of chronic pain. The objective of this article is to provide a rationale for using improvement in sleep as a marker for effective management of chronic OA pain with opioid analgesics. For this purpose, available evidence evaluating the relationship between successful management of chronic pain with opioids and improvements in sleep in patients with OA is reviewed. ⋯ Current evidence suggests that various long-acting opioid analgesics simultaneously achieve pain control and improve sleep. However, the complex interaction between reduced pain and improved sleep requires further study.