Seminars in arthritis and rheumatism
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Semin. Arthritis Rheum. · Oct 2015
Meta AnalysisRisk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials.
Methotrexate is an effective treatment for a variety of inflammatory diseases. Robust evidence on the risk of serious liver injury is lacking. The aim of this study was to evaluate the relative risk and severity of liver disease among patients treated with methotrexate. ⋯ Our study found an increased risk of elevated transaminases but not liver failure, cirrhosis or death with methotrexate compared to other agents. We were unable to assess long-term liver toxicity due to the short duration of included clinical trials.