Seminars in arthritis and rheumatism
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Semin. Arthritis Rheum. · Jun 2010
Randomized Controlled Trial Multicenter StudyLong-term safety, tolerability, and efficacy of duloxetine in the treatment of fibromyalgia.
To assess the long-term safety, tolerability, and efficacy of duloxetine in patients with fibromyalgia. ⋯ These findings support a positive risk/benefit profile for duloxetine in the long-term treatment of fibromyalgia.
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Semin. Arthritis Rheum. · Dec 2009
Randomized Controlled TrialRandomized controlled trial of diclofenac sodium gel in knee osteoarthritis.
Nonsteroidal anti-inflammatory drugs have dose-related adverse effects. Topical nonsteroidal anti-inflammatory drugs may offer local efficacy with low systemic drug levels. This study assessed the efficacy and safety of topical diclofenac sodium 1% gel (DSG) in mild to moderate symptomatic knee osteoarthritis. ⋯ Over a 3-month treatment period, topical treatment with DSG achieved statistically and clinically significant improvements of pain and measures of physical function in patients with knee osteoarthritis.
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Semin. Arthritis Rheum. · Aug 2009
Randomized Controlled Trial Multicenter StudyA double-blind, randomized, saline-controlled study of the efficacy and safety of EUFLEXXA for treatment of painful osteoarthritis of the knee, with an open-label safety extension (the FLEXX trial).
To report the FLEXX trial, the first well-controlled study assessing the safety and efficacy of Euflexxa (1% sodium hyaluronate; IA-BioHA) therapy for knee osteoarthritis (OA) at 26 weeks. ⋯ IA-BioHA therapy resulted in significant OA knee pain relief at 26 weeks compared with IA-SA. Subjects treated with IA-BioHA also experienced significant improvements in joint function, treatment satisfaction, and HRQoL.