Anesthesia and analgesia
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Anesthesia and analgesia · Oct 2006
Epidural lidocaine induces dose-dependent neurologic injury in rats.
Although epidural lidocaine administered as a bolus has been shown to cause little neurotoxicity, local anesthetics are often administered repetitively or continuously into the epidural space, and in high doses may induce neurologic injury. We investigated whether epidural lidocaine is neurotoxic when a large dose is continuously administered in rats, and whether the functional impairment and histologic damage is dose dependent. In Experiment 1, 13 rats received a 120-min epidural infusion (at 5 microL/min) of saline or 2% lidocaine. ⋯ Nerve injury scores for rats given 5% lidocaine for 30, 60, and 120 min were significantly higher than those for rats given saline. Significant difference in damage in nerve roots was also observed among rats given the anesthetic for different durations of time; nerve injury scores with 120-min infusion were higher than with 15- and 30-min infusions, and injury with 60-min infusion was greater than with 15-min infusion. In conclusion, these results suggest that epidural lidocaine causes dose-dependent neurotoxicity after continuous infusion in rats.
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Anesthesia and analgesia · Oct 2006
Letter Case ReportsPropofol infusion syndrome--a fatal case at a low infusion rate.
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Anesthesia and analgesia · Oct 2006
Editorial CommentDon't confuse the anesthetic with the anesthesiologist!