Anesthesia and analgesia
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Anesthesia and analgesia · Jan 2007
Xenon blocks the induction of synaptic long-term potentiation in pain pathways in the rat spinal cord in vivo.
Xenon's (Xe) mechanisms for producing anesthesia and analgesia are not fully understood. We tested the effect of Xe equilibrated in a lipid formulation or normal saline on spinal C-fiber-evoked potentials and on the induction of synaptic long-term potentiation (LTP). ⋯ Low-dose Xe in saline 0.9% revealed no antinociceptive, but preventive, action in spinal pain pathways.
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Anesthesia and analgesia · Jan 2007
The hypnotic, electroencephalographic, and antinociceptive properties of nonpeptide ORL1 receptor agonists after intravenous injection in rodents.
Agonists at the opioid receptor-like receptor 1 (ORL1) induce motor impairment, sedation, and loss of righting reflex (LRR) in rodents. This receptor may provide a novel target in the field of anesthesia. ⋯ These results show that Ro 65-6570 and Org 26383 (probably via the ORL1 receptor) behave as IV hypnotics and analgesics in mice and rats, and that the hypnotic and antinociceptive doses are similar.
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Anesthesia and analgesia · Jan 2007
Letter Case ReportsAnesthetic implications of a near-lethal sodium azide exposure.