Anesthesia and analgesia
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Anesthesia and analgesia · May 2007
Comparative StudyProlongation of intrathecal and sciatic nerve blocks using a complex of levobupivacaine with maltosyl-beta-cyclodextrin in rats.
We used a cyclodextrin-based drug delivery system, consisting of levobupivacaine complexed with maltosyl-beta-cyclodextrin (G2-beta-CD), in spinal and sciatic nerve blocks in rats to investigate prolongation of the local anesthetic effect. ⋯ The complex of levobupivacaine with G2-beta-CD prolonged the anesthetic effect of levobupivacaine in both intrathecal and sciatic nerve blocks in rats.
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Anesthesia and analgesia · May 2007
Comparative StudyRefinement of symptoms of neuropathic pain measurements after various transections of the nerve endings of the sciatic and femoral nerve in rats: an exploratory behavioral analysis.
Many animal models can be used to study the underlying pathophysiological mechanisms of neuropathic pain. Most of these models rely on a partial denervation of the limb of the animal by ligating a selected nerve. In this study, we performed nerve lesions on three peripheral nerves supplying the plantar side of the rat hindpaw by differentially transecting the saphenous, the tibial, and the sural nerves alone or in paired combinations. ⋯ The overlapping innervation of nerve distribution can complicate the interpretation of nerve ligation studies of peripheral neuropathies.
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Anesthesia and analgesia · May 2007
Case ReportsThe novel use of computer-generated virtual imaging to assess the difficult pediatric airway.
In a patient with a known difficult airway, history and examination may be of limited use in formulating a management plan for subsequent tracheal intubation. Further detailed and descriptive review of the airway is necessary. ⋯ It creates a movie clip image of the upper airway akin to the view obtained through a fiberscope. We present a patient with Goldenhar syndrome in whom virtual imaging was used to identify the cause of a previous failed tracheal intubation.
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Anesthesia and analgesia · May 2007
Case ReportsVisual loss in a prone-positioned spine surgery patient with the head on a foam headrest and goggles covering the eyes: an old complication with a new mechanism.
A patient developed central retinal artery occlusion during surgery in the prone position with eye protectors placed over his eyes. We discuss the potential hazards of using such a device (the Dupaco Opti-Gard) in this setting.
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Anesthesia and analgesia · May 2007
Comparative StudyDextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats.
Dextromethorphan blocks sodium channels, the site of action of local anesthetics. In this study we evaluated whether dextromethorphan has a local anesthetic effect. ⋯ Dextromethorphan and dextrorphan were more potent local anesthetics than lidocaine, but with higher systemic safety indices. Coadministration of dextromethorphan or dextrorphan with lidocaine produced an additive effect.