Anesthesia and analgesia
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Anesthesia and analgesia · May 2007
Comparative StudyProlongation of intrathecal and sciatic nerve blocks using a complex of levobupivacaine with maltosyl-beta-cyclodextrin in rats.
We used a cyclodextrin-based drug delivery system, consisting of levobupivacaine complexed with maltosyl-beta-cyclodextrin (G2-beta-CD), in spinal and sciatic nerve blocks in rats to investigate prolongation of the local anesthetic effect. ⋯ The complex of levobupivacaine with G2-beta-CD prolonged the anesthetic effect of levobupivacaine in both intrathecal and sciatic nerve blocks in rats.
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Anesthesia and analgesia · May 2007
The "axillary tunnel": an anatomic reappraisal of the limits and dynamics of spread during brachial plexus blockade.
Various anatomic factors have been described as affecting the distribution of a solution injected around the brachial plexus. Using computerized axial tomography dye studies, we introduce a new concept. ⋯ We conclude that the brachial plexus is contained within a rigid-walled tunnel of variable dimensions, which we call the "axillary tunnel." The scapula/subscapularis complex, related to the subcoracoid point of resistance, may account for the differing patterns of dye distribution observed.
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Anesthesia and analgesia · May 2007
Comparative StudyDextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats.
Dextromethorphan blocks sodium channels, the site of action of local anesthetics. In this study we evaluated whether dextromethorphan has a local anesthetic effect. ⋯ Dextromethorphan and dextrorphan were more potent local anesthetics than lidocaine, but with higher systemic safety indices. Coadministration of dextromethorphan or dextrorphan with lidocaine produced an additive effect.