Anesthesia and analgesia
-
Anesthesia and analgesia · Feb 2010
The effects of vasoactive drugs on intestinal functional capillary density in endotoxemic rats: intravital video-microscopy analysis.
The use of vasoactive drugs to restore arterial blood pressure in patients with septic shock remains a cornerstone of intensive care medicine. However, vasopressors can accentuate the hypoperfusion of the gut during septic shock, allowing bacterial translocation and endotoxemia. In this study, we compared the effects of different vasoactive drugs on intestinal microcirculation and tissue oxygenation, independent of the effects of fluid therapy, in a rat model of endotoxemic shock. ⋯ This study confirms dissociation of the systemic hemodynamic and microvascular alterations in an experimental model of septic shock. Moreover, the results indicate that the use of dopamine, dobutamine, and dobutamine in combination with norepinephrine yields a protective effect on the microcirculation of the intestinal muscular layer in endotoxemic rats.
-
Anesthesia and analgesia · Feb 2010
What's new in obstetric anesthesia: the 2009 Gerard W. Ostheimer lecture.
This article summarizes the most relevant publications in obstetric anesthesiology from 2008. Forty-two articles were selected from a pool of several thousand in >70 English-language journals that were deemed as having the most impact on the practice of obstetric anesthesia.