Anesthesia and analgesia
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Anesthesia and analgesia · Feb 2010
What's new in obstetric anesthesia: the 2009 Gerard W. Ostheimer lecture.
This article summarizes the most relevant publications in obstetric anesthesiology from 2008. Forty-two articles were selected from a pool of several thousand in >70 English-language journals that were deemed as having the most impact on the practice of obstetric anesthesia.
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Anesthesia and analgesia · Feb 2010
Transgenic Alzheimer mice have a larger minimum alveolar anesthetic concentration of isoflurane than their nontransgenic littermates.
More than 12% of all people older than 65 yr have Alzheimer's disease. Because nothing is known about changes in demand of volatile anesthetics in this disease, we determined minimum alveolar anesthetic concentration (MAC) values of isoflurane in young and aged transgenic mice at risk of developing Alzheimer's disease (heterozygote APP23 mice with the "Swedish double mutation"). To differentiate between unspecific effects of the transgenic model and specific Alzheimer effects, we additionally evaluated MAC values in mice with the same genetic construct but without the Alzheimer's disease-causing Swedish double mutation (heterozygote APP51/16 mice). ⋯ The increased MAC value in aged heterozygote APP23 mice seems to be attributable to changes related to Alzheimer's disease.