Anesthesia and analgesia
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Anesthesia and analgesia · Feb 2010
The C-MAC videolaryngoscope: first experiences with a new device for videolaryngoscopy-guided intubation.
We studied the efficacy of the C-MAC (Karl Storz, Tuttlingen, Germany), a new portable videolaryngoscope, in 60 patients during routine induction of anesthesia. It was possible to insert the blade (Size 3) of the C-MAC and to get a view of the glottis on the first attempt in all patients. Tracheal intubation also was successful in all 60 patients; 52 patients were intubated on the first attempt, 6 on the second, and 2 on the third. ⋯ The median time taken for tracheal intubation was 16 s (range, 6-58 s). In addition, we describe our experience with 3 patients in whom we had unexpected difficulty with direct laryngoscopy with a conventional Macintosh laryngoscope (Cormack-Lehane Class 3, 4, and 4, respectively). These patients' airways were successfully managed on the first attempt when using the C-MAC Size 4 blade (improvement to Cormack-Lehane Class 1, 2a, and 2b, respectively) in a modified manner by uploading the epiglottis, which is known as "straight blade technique."
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Anesthesia and analgesia · Feb 2010
Case ReportsAcute intraoperative neurogenic pulmonary edema during endoscopic ventriculoperitoneal shunt revision.
We present an incident of fulminant intraoperative neurogenic pulmonary edema in a 21-yr-old man undergoing an endoscopic ventriculoperitoneal shunt revision. His intraoperative course was complicated by intracranial bleeding requiring vigorous saline irrigation, which was accompanied by an acute increase in heart rate and arterial blood pressure. Shortly thereafter, the patient developed pulmonary edema and was promptly treated with resolution of pulmonary symptoms within 24 h. This report addresses the importance of recognition of neurogenic pulmonary edema as a possible intraoperative complication resulting from an increase in intracranial pressure due to hemorrhage and intraventricular irrigation during endoscopic ventriculoperitoneal shunt revision.
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Anesthesia and analgesia · Feb 2010
High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.
In 2 separate centers, we observed a notable increase in the incidence of postoperative convulsive seizures from 1.3% to 3.8% in patients having undergone major cardiac surgical procedures. These events were temporally coincident with the initial use of high-dose tranexamic acid (TXA) therapy after withdrawal of aprotinin from general clinical usage. The purpose of this review was to perform a retrospective analysis to examine whether there was a relation between TXA usage and seizures after cardiac surgery. ⋯ Our results suggest that use of high-dose TXA in older patients in conjunction with cardiopulmonary bypass and open-chamber cardiac surgery is associated with clinical seizures in susceptible patients.
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Anesthesia and analgesia · Feb 2010
The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model.
Glycinergic neurons in the spinal dorsal horn have been implicated in the inhibition of spinal pain processing in peripheral inflammation and chronic pain states. Neuronal isoform glycine transporter-2 (GlyT2) reuptakes presynaptically released glycine and regulates the glycinergic neurotransmission. In this study, we examined whether a selective GlyT2 inhibitor, ALX1393, elicits an antinociceptive effect in a rat acute pain model. ⋯ This study demonstrates the antinociceptive action of ALX1393 on acute pain. These findings suggest that the inhibitory neurotransmitter transporters are promising targets for the treatment of acute pain and that the selective inhibitor of GlyT2 could be a novel therapeutic drug.