Anesthesia and analgesia
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Anesthesia and analgesia · May 2017
Observational StudyThe Association of Frailty With Outcomes and Resource Use After Emergency General Surgery: A Population-Based Cohort Study.
Older patients undergoing emergency general surgery (EGS) experience high rates of postoperative morbidity and mortality. Studies focused primarily on elective surgery indicate that frailty is an important predictor of adverse outcomes in older surgical patients. The population-level effect of frailty on EGS is poorly described. Therefore, our objective was to measure the association of preoperative frailty with outcomes in a population of older patients undergoing EGS. ⋯ After EGS, frailty is associated with increased rates of mortality, institutional discharge, and resource use. Strategies that might improve perioperative outcomes in frail EGS patients need to be developed and tested.
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Anesthesia and analgesia · May 2017
Inhaled Remimazolam Potentiates Inhaled Remifentanil in Rodents.
Remimazolam is an ester-based short-acting benzodiazepine currently in clinical trials for IV administration. This study explored the feasibility of delivering remimazolam alone and as an adjunct to remifentanil via inhalation in rodent models. ⋯ Remimazolam can significantly potentiate the analgesic effect of remifentanil when concurrently delivered via inhalation.