Anesthesia and analgesia
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Anesthesia and analgesia · Aug 2020
Comparative Study Observational StudyAnesthesia With and Without Nitrous Oxide and Long-term Cognitive Trajectories in Older Adults.
Although exposure to surgery/anesthesia is associated with a small cognitive decline among the elderly, there is no impact from the presence or absence of nitrous oxide.
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Anesthesia and analgesia · Aug 2020
Randomized Controlled TrialA Prospective, Randomized, Double-Blinded Study of the Effect of Intravenous Ondansetron on the Effective Dose in 50% of Subjects of Prophylactic Phenylephrine Infusions for Preventing Spinal Anesthesia-Induced Hypotension During Cesarean Delivery.
Pre-spinal-anaesthesia administration of IV ondansetron 4 mg reduces the ED50 of prophylactic phenylephrine infusion by 26% among patients undergoing elective Caesarean section.
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Anesthesia and analgesia · Aug 2020
Randomized Controlled TrialEffect of Different Concentrations of Propofol Used as a Sole Anesthetic on Pupillary Diameter: A Randomized Trial.
Propofol has a dose-dependent effect on pupillary diameter, which is positively correlated with BIS.
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Anesthesia and analgesia · Aug 2020
Randomized Controlled Trial Comparative StudyMcGrath Video Laryngoscope Versus Macintosh Direct Laryngoscopy for Intubation of Morbidly Obese Patients: A Randomized Trial.
The McGrath video laryngoscope improves glottis visualisation in the morbidly obese.
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Anesthesia and analgesia · Aug 2020
ReviewA Guide to Understanding "State-of-the-Art" Basic Research Techniques in Anesthesiology.
Perioperative medicine is changing from a "protocol-based" approach to a progressively personalized care model. New molecular techniques and comprehensive perioperative medical records allow for detection of patient-specific phenotypes that may better explain, or even predict, a patient's response to perioperative stress and anesthetic care. Basic science technology has significantly evolved in recent years with the advent of powerful approaches that have translational relevance. ⋯ This review focuses on 3 important and most likely practice-changing basic science techniques: next-generation sequencing (NGS), clustered regularly interspaced short palindromic repeat (CRISPR) modulations, and inducible pluripotent stem cells (iPSCs). Each technique will be described, potential advantages and limitations discussed, open questions and challenges addressed, and future developments outlined. We hope to provide insight for practicing physicians when confronted with basic science articles and encourage investigators to apply "state-of-the-art" technology to their future experiments.