Anesthesia and analgesia
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Anesthesia and analgesia · Oct 1994
Randomized Controlled Trial Comparative Study Clinical TrialComparative vascular effects of midazolam and lorazepam administered during cardiopulmonary bypass.
We studied the comparative vascular effects of midazolam and lorazepam in 52 patients undergoing elective cardiac surgery procedures. After administration of fentanyl, 100 micrograms/kg intravenously, the patients were randomized to receive either midazolam 0.1 mg/kg (M high), midazolam 0.05 mg/kg (M low), lorazepam 0.1 mg/kg (L high), lorazepam 0.05 mg/kg (L low), or placebo during cardiopulmonary bypass (CPB). Compared to the placebo and L-low groups, the high-dose midazolam group had more effect on systemic vascular resistance (SVR) starting at 5 min after study drug administration (P < 0.02). ⋯ In the first 12 h of the postoperative period, the M-high group required phenylephrine (PHE) infusion for hypotension associated with decreased SVR more often than placebo (8/10 vs 1/11 patients, P < 0.008, chi 2). In conclusion, midazolam more effectively attenuated the increase in SVR that occurred during CPB than patients receiving either placebo or lorazepam. The hemodynamic effects from a single dose of 0.1 mg/kg midazolam administered at the start of CPB may persist into the postoperative period.
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Anesthesia and analgesia · Oct 1994
Randomized Controlled Trial Clinical TrialPrevention of endotracheal tube-induced coughing during emergence from general anesthesia.
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Anesthesia and analgesia · Oct 1994
Body position does not affect the hemodynamic response to venous air embolism in dogs.
Current therapy for massive venous air embolism (VAE) includes the use of the left lateral recumbent (LLR) position. This recommendation is based on animal studies, conducted 50 yr ago, which looked primarily at survival. Little is known, however, about the concomitant hemodynamic response after VAE in various body positions. ⋯ The acute hemodynamic changes occurring during the first 5-15 min after VAE recovered to 80% of control within 60 min. Our data suggest that body repositioning does not influence the cardiovascular response to VAE. Specifically, our data do not support the recommendation of repositioning into the LLR position for the treatment of VAE.
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Anesthesia and analgesia · Oct 1994
Prevention of occupational transmission of human immunodeficiency virus and hepatitis B virus among anesthesiologists: a survey of anesthesiology practice.
In light of the increasing prevalence of the human immunodeficiency virus (HIV) and hepatitis B virus (HBV), anesthesiologists are now likely to see more patients who are at high risk for these viruses. Therefore, it is important that they adopt infection control policies aimed at preventing occupational transmission of these and other pathogens during their clinical practice. This study was designed, using a questionnaire format, to evaluate anesthesiologist compliance with Centers for Disease Control (CDC) guidelines for the prevention of occupational transmission of HIV and HBV. ⋯ However, anesthesiologists who reported recapping needles using the one-handed technique were less likely to sustain a needlestick injury than those who recapped using the two-handed technique. Thirty-one percent and 72% of respondents respectively reported a clean or contaminated needlestick within the preceeding 12 mo. Only 45.4% of those receiving a contaminated needlestick sought treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
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Anesthesia and analgesia · Oct 1994
Comparative StudyIntracranial volume/pressure relationship during desflurane anesthesia in dogs: comparison with isoflurane and thiopental/halothane.
Desflurane-induced increase of intracranial pressure (ICP) does not appear to be completely explained by desflurane-induced changes in cerebral blood flow, cerebrospinal fluid (CSF) formation and reabsorption, or brain tissue water content. The present study was designed to determine whether desflurane alters intracranial volume/pressure relationships sufficiently to account for desflurane-induced increase of ICP. In 24 dogs, infusions of mock CSF were used to determine the CSF pressure increase due to increase of CSF volume, and the capacity of CSF pressure to return to baseline after a CSF pressure increase (CSF pressure normalization). ⋯ However, desflurane and isoflurane had no consistent effect on the other measures of CSF pressure increase caused by increase of CSF volume. Isoflurane also decreased the capacity for CSF pressure normalization at normal CSF pressure as indicated by decreased S1 and increased delta Ps. It is concluded that, under conditions of normal ICP, desflurane may decrease Ce, favoring an increase of ICP.