Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Jan 2022
CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival.
Cell division cycle 25c (CDC25c) is a gene coding a phosphatase controlling entry into mitosis upon activation through Polo-like kinase 1 (PLK1) and serves as a key regulator of cell division. The CDC25c was reported to be dysregulated in some malignant diseases, but its role in myelofibrosis has not yet been elucidated. ⋯ Our data suggest that higher CDC25c expression is associated with more proliferative phenotype of myelofibrosis and is prognostic of worse survival. Future studies investigating these interesting associations are warranted.
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Wien. Klin. Wochenschr. · Jan 2022
Diabetic foot complications-lessons learned from real-world data derived from a specialized Austrian hospital.
Diabetic foot complications, one of the most severe late complications of type 2 diabetes mellitus, are associated with a tremendous personal and financial burden. In order to drive the prevention of diabetic foot complications forward and facilitate early detection and personalized screening of high-risk patients, longitudinal studies are needed to identify risk factors associated with diabetic foot complications in large patient datasets. ⋯ The identified risk factors for diabetic foot complications suggest that personalized early detection of patients at high risk might be possible by taking the patient's clinical characteristics, medical history and comorbidities into account. Modifiable risk factors, such as hypertension and high levels of blood glucose might be tackled to reduce the risk for diabetic foot complications.
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Wien. Klin. Wochenschr. · Jan 2022
Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkin's lymphoma patients.
We retrospectively investigated clinical and prognostic significance of psoas muscle index (PMI) calculated as total psoas muscle area at L3 vertebra level obtained from baseline computed tomography (CT) scans in 49 newly diagnosed classical Hodgkin's lymphoma (cHL) patients prior to specific treatment. Median PMI was 572.5 mm2/m2 and was significantly higher in males (P < 0.001), patients with higher body mass index (BMI, P < 0.001), absence of extranodal disease (P = 0.037), higher absolute lymphocyte count (P = 0.037), higher hemoglobin (P = 0.010) and lower lactate dehydrogenase (LDH, P = 0.050). ⋯ Patients with lower PMI had significantly worse PFS (hazard ratio [HR] 4.91; P = 0.009). This phenomenon persisted in the multivariate model (HR = 5.09; P = 0.042) adjusted for International Prognostic Score (IPS) and chemotherapy type.
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Wien. Klin. Wochenschr. · Jan 2022
FDA warning montelukast 03.2020-Statement of the Austrian working group of pediatric pulmonology and allergology.
Montelukast, a leukotriene receptor antagonist (LTRA) has been approved for use in Europe since 1998. Indications for use (from the age of 6 months) include mild to moderate asthma, seasonal allergic rhinitis with asthma, and the prevention of exercise-induced asthma episodes. ⋯ In this statement the Austrian working group of pediatric pulmonology and allergology advises that treatment with montelukast should be started only after critical evaluation. Treatment should be stopped on the occurrence of any neuropsychiatric side effects.
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Wien. Klin. Wochenschr. · Jan 2022
Clinical risk factors for recurrence of pelvic organ prolapse after primary native tissue prolapse repair.
To define potential risk factors for recurrence of prolapse. ⋯ Initial proper preoperative counseling is of particular importance to modulate patients' expectations after prolapse surgery.