Epilepsia
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Multicenter Study Comparative Study
Differential effects of temporal pole resection with amygdalohippocampectomy versus selective amygdalohippocampectomy on material-specific memory in patients with mesial temporal lobe epilepsy.
In the surgical treatment of mesial temporal lobe epilepsy, there is converging evidence that individually tailored or selective approaches have a favorable cognitive outcome compared to standard resections. There is, however, also evidence that due to collateral damage, selective surgery can be less selective than suggested. As part of a prospective transregional research project the present study evaluated the outcome in memory and nonmemory functions, following two selective approaches: a combined temporal pole resection with amygdalohippocampectomy (TPR+) and transsylvian selective amygdalohippocampectomy (SAH). ⋯ The results indicate a differential effect of left/right SAH versus TPR+ on material-specific memory insofar as transsylvian SAH appears to be favorable in right and TPR+ in left MTLE. The different outcomes are discussed in terms of a different surgical affection of the temporal pole and stem, and different roles of these structures for verbal and figural memory.
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Multicenter Study Comparative Study
Defining the spectrum of international practice in pediatric epilepsy surgery patients.
The Pediatric Epilepsy Surgery Sub-commission of the International League Against Epilepsy conducted a survey to determine the frequency of epilepsy procedures and etiologies. ⋯ The results of this international survey show the feasibility of international collaborations in determining epilepsy etiologies and procedures in children, and suggest differences in clinical practice between regions of the world. These results can guide the design of future studies in producing guidelines for therapy-resistant pediatric epilepsy surgery patients.