International journal of dermatology
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Randomized Controlled Trial Clinical Trial
Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC-KUS).
Low catalase levels and cellular vacuolation in the epidermis of patients with vitiligo support major oxidative stress in this compartment. There is now in vivo evidence for increased epidermal hydrogen peroxide (H(2)O(2)) accumulation in this patient group by utilizing noninvasive Fourier Transform Raman spectroscopy (FT Raman). Epidermal H(2)O(2) can be removed with a topical application of narrow band UVB activated pseudocatalase cream (PC-KUS). (Mn/EDTA-bicarbonate complex, patent No. EPO 58471 1 A), yielding initiation of repigmentation. Dead Sea climatotherapy is another successful treatment modality for vitiligo, but the mode of action has escaped definition so far. ⋯ The results of this study show a significantly faster initiation of repigmentation in vitiligo after a combination of short-term climatotherapy (21 days) at the Dead Sea in combination with a pseudocatalase cream (PC-KUS) compared to either conventional climatotherapy at the Dead Sea alone or with placebo cream in combination with climatotherapy. This combined therapy is significantly faster in repigmentation than narrowband UVB activated pseudocatalase cream (PC-KUS) treatment alone. The results of this study support the necessity of epidermal H2O2 removal as well as the influence of solar UV-light in the successful treatment of vitiligo.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
The effects of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing. Cadexomer Iodine Study Group.
The aim was to examine cadexomer iodine paste in a comparative clinical trial. ⋯ This study shows that cadexomer iodine paste is an efficient, cost-effective and safe alternative to hydrocolloid dressing and paraffin gauze dressing for the treatment of venous leg ulcers.
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Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
Malathion lotion as an insecticide and ovicide in head louse infestation.
A lotion containing 0.5% malathion was compared with its vehicle (control) in a double-blind, parallel-group study of 119 patients with head louse infestations confirmed by live ova in the hair. The lotions remained in place for 8 hours. ⋯ It also proved superior to the vehicle (p less than 0.001) as an ovicidal agent, judged by comparative differences in hatching rates between nits collected and incubated before treatment and those obtained and incubated after treatment. No adverse reaction occurred.
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Randomized Controlled Trial Comparative Study Clinical Trial
Clinical comparison of desonide cream with betamethasone valerate cream. A double-blind randomized study.