Headache
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Multicenter Study Clinical Trial
Nefazodone for chronic daily headache prophylaxis: an open-label study.
To assess effectiveness, tolerability, and safety of nefazodone as a prophylactic agent for chronic daily headache. ⋯ These results provide preliminary support for the efficacy of nefazodone in the prophylaxis of chronic daily headache. In this sample, nefazodone was safe and generally well tolerated. Patient ratings of sexual function improved over the course of treatment, in contrast to what is generally observed with most antidepressants. Nefazodone may be particularly beneficial for patients with chronic daily headache and comorbid depression. Further research is indicated.