Headache
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Randomized Controlled Trial
Tramadol/acetaminophen for the treatment of acute migraine pain: findings of a randomized, placebo-controlled trial.
To compare tramadol/acetaminophen (APAP) and placebo for the management of acute migraine pain. ⋯ Tramadol/APAP reduces the severity of pain, photophobia, and phonophobia associated with migraine headache, but does not reduce migraine-associated nausea. Tramadol/APAP might be an appropriate option for the management of moderate-to-severe migraine headache.
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Randomized Controlled Trial
Topiramate for migraine prevention in children: a randomized, double-blind, placebo-controlled trial.
To assess the efficacy and safety of topiramate for the prevention of pediatric migraine with or without aura in a double-blind, randomized, placebo-controlled trial. ⋯ This pilot study suggests that topiramate may be an effective migraine preventive therapy in children. Topiramate was well tolerated in this population. Further randomized studies would be required to definitively establish the efficacy of topiramate for pediatric migraine prevention.
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To assess the evolution of headaches in a workplace cohort over a 10-year period. ⋯ Only a minority of subjects diagnosed with migraine or migrainous disorder retain the diagnosis 10 years later, with most subjects evolving to a less disabling headache type.