Headache
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Randomized Controlled Trial
Long-term migraine prevention with topiramate: open-label extension of pivotal trials.
To demonstrate that topiramate is an effective and generally well-tolerated migraine preventive therapy when used for up to 14 months. ⋯ Patients receiving topiramate experienced a sustained reduction in migraine frequency for up to 14 months. The effectiveness and safety of topiramate was consistent with that observed during 2 26-week pivotal trials.