Headache
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Randomized Controlled Trial Comparative Study
A double-blind comparison of onabotulinumtoxina (BOTOX) and topiramate (TOPAMAX) for the prophylactic treatment of chronic migraine: a pilot study.
There is a need for effective prophylactic therapy for chronic migraine (CM) that has minimal side effects. ⋯ OnabotulinumtoxinA and topiramate demonstrated similar efficacy in the prophylactic treatment of CM. Patients receiving onabotulinumtoxinA had fewer AEs and discontinuations.