Headache
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Randomized Controlled Trial
Evaluation of carisbamate for the treatment of migraine in a randomized, double-blind trial.
This study explored the dose-response relationship of carisbamate administered at doses of 100 mg per day, 300 mg per day, or 600 mg per day, in the prevention of migraine. ⋯ Carisbamate was not more efficacious in migraine prophylaxis than placebo in this well-controlled study that included a suitable population. However, carisbamate monotherapy was well tolerated at doses up to 600 mg per day.
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Case Reports
Intravenous lidocaine infusion for the treatment of post-acoustic neuroma resection headache: a case report.
Presentation of a case report of a 47-year-old male with a post-acoustic neuroma resection intractable headache responding to intravenous lidocaine infusion. The patient was then switched to mexiletine, with good response.
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Few studies in adolescents deal with the level of agreement between questionnaire and interview information in relation to headache symptoms. ⋯ The results indicate that our self-administered questionnaire may be an acceptable instrument in determining the prevalence of migraine sufferers in the northeast Italy adolescent population, useful in identifying subjects with "definite" migraine.
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Despite the high level of individual and societal burden resulting from headache disorders, the National Institutes of Health (NIH) has funded relatively little research on these disorders. ⋯ A small number of research grants on headache disorders were funded by the NIH over the last 2 decades, with 2007 funding estimated between $6.8 and $13 million. By comparison to NIH funding of research on 10 chronic medical conditions relative to disease burden, headache research funding should exceed $103 million annually.
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To investigate a clinical population of patients with hemicrania continua (HC), looking at the diagnostic problems they have encountered and their use of healthcare resources and at issues relating to the effectiveness of treatments. ⋯ Hemicrania continua may be misdiagnosed and mistreated even by neurologists. There is a need for greater awareness and understanding of this condition.