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Anaphylactic reactions reveal the maximal grade of allergic reactions and are potentially life-threatening. The most common agents involved in anaphylactic reactions are drugs, food, Hymenoptera, aeroallergens, Latex, and physical stress. Anaphylactic reactions are induced by the liberation of various mediators. ⋯ Adequate therapy has to be given immediately according to the severity of symptoms in a step-wise approach. In the specific drug-therapy, a few substances have proved to be reliable, e.g. adrenalin, histamine antagonists, glucocorticosteroids, oxygen and volume substitutes. This article provides an overview of prevalence, symptoms and therapeutic options for managing anaphylaxis.