Journal of neurochemistry
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Journal of neurochemistry · Nov 2015
Editorial CommentAn integrated energy plan for activated neurons.
This Editorial highlights an ingenious study by Li and Freeman published in this issue of J. Neurochem. ⋯ To that end, the authors have designed a new approach that consists to record at the same time (100 ms resolution) extracellular glucose and lactate concentrations using electrochemical sensing microelectrodes equally distant from a microelectrode that registers the multicellular activity in response to light-dependent stimuli (contrast levels from 10% to 80%). While this approach does, however, not evaluate the metabolic coupling between astrocytes and neurons, it proposes a new design which combined with molecular strategies specifically toward the glial or neuronal compartments will certainly help to demonstrate new distinctive features of this interesting question.