Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
ReviewStereotactic radiosurgery for primary trigeminal neuralgia: state of the evidence and recommendations for future reports.
To identify systematically all the studies reporting outcomes and complications of stereotactic radiosurgery for trigeminal neuralgia and to evaluate them against predefined quality criteria. ⋯ Outcomes after stereotactic radiosurgery appear in line with other ablative techniques. Results are better when it is used as primary treatment in patients with typical symptoms. Current data are largely observational and the quality is generally poor. This technique should be evaluated in a randomised, controlled trial with universal outcome measures, actuarial methodology, and validated measures of patient satisfaction and quality of life.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Meta AnalysisTau gene and Parkinson's disease: a case-control study and meta-analysis.
To investigate whether the tau H1 haplotype is a genetic risk factor in Parkinson's disease and to report a meta-analysis on all previously published data ⋯ Homozygosity for the tau H1 is associated with an increased risk of Parkinson's disease. This adds to the growing body of evidence that common genetic variation contributes to the pathogenesis of this disorder.
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Botulinum toxin, the most potent biological toxin, has become a powerful therapeutic tool for a growing number of clinical applications. This review draws attention to new findings about the mechanism of action of botulinum toxin and briefly reviews some of its most frequent uses, focusing on evidence based data. ⋯ When injected not more often than every three months, the risk of blocking antibodies is slight. Long term experience with this agent suggests that it is an effective and safe treatment not only for approved indications but also for an increasing number of off-label indications.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Effects of surgery on the sensory deficits of syringomyelia and predictors of outcome: a long term prospective study.
To quantify the effects of surgery on the thermal deficits of syringomyelia and assess the predictors for such effects. ⋯ The duration of sensory deficits is the best predictive factor of the efficacy of surgery for the thermal symptoms of syringomyelia. Early surgery is required if these deficits are to be minimised.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Clinical TrialThe effect of immunomodulatory treatment on multiple sclerosis fatigue.
To assess the effects of glatiramer acetate and beta interferon on fatigue in multiple sclerosis. ⋯ The odds of reduced multiple sclerosis fatigue were around twice as great with glatiramer acetate treatment as with beta interferon. Confirmation of this result is required.