Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Aug 2012
Reduced R2' in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron content.
R(2)' is an MRI measure of microscopic magnetic field inhomogeneity, and is increased by the paramagnetic effect of iron and the diamagnetic effect of myelin. R(2)' may detect features of multiple sclerosis (MS) not evident with conventional MRI. ⋯ Reduction in R(2)' in NAWM and lesions is consistent with a decreases in myelin, tissue iron and/or deoxyhaemoglobin. Increased caudate R(2)' in patients with secondary progressive MS is consistent with increased iron deposition, as corroborated by other techniques.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2012
Cortical border-zone infarcts: clinical features, causes and outcome.
To report the clinical features, causes and outcome of cerebral cortical border-zone infarcts BZI (C-BZI). ⋯ Some clinical features are overrepresented in such infarctions, including initial transient symptoms preceding the onset of a completed deficit, transcortical aphasia and early seizures. Despite lower initial severity, C-BZIs justify early management in stroke unit, often followed by carotid surgery, leading to an overall good prognosis.