Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Aug 2015
The network topology of aneurysmal subarachnoid haemorrhage.
Network analysis is an emerging tool for the study of complex systems. In the current report, the cascade of physiological and neurological changes following aneurysmal subarachnoid haemorrhage (SAH) was modelled as a complex system of interacting parameters. Graph theoretical analysis was then applied to identify parameters at critical topological junctions of the network, which may represent the most effective therapeutic targets. ⋯ Using graph theoretical analysis, we identify critical network topologies following SAH, which may serve as useful therapeutic targets. Importantly, we demonstrate that network analysis is a robust method to model complex interactions following SAH.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2015
Observational StudyPost-stroke fatigue: a problem of altered corticomotor control?
We recently showed that diminished motor cortical excitability is associated with high levels of post-stroke fatigue. Motor cortex excitability impacts movement parameters such as reaction and movement times. We predicted that one or both would be influenced by the presence of post-stroke fatigue. ⋯ Previously, we showed that motor cortex excitability is lower in patients with high post-stroke fatigue. Our current findings suggest that post-stroke fatigue (1) is a problem of movement speed (possibly a consequence of diminished motor cortex excitability) and not movement preparation, and (2) may have a focal origin confined to the lesioned hemisphere. We suggest that low motor cortex excitability in the lesioned hemisphere is a viable therapeutic target in post-stroke fatigue.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2015
Hypoglossal-facial nerve 'side'-to-side neurorrhaphy using a predegenerated nerve autograft for facial palsy after removal of acoustic tumours at the cerebellopontine angle.
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