Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Aug 2019
High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis.
To determine whether persistent organic pollutants (POP) affect amyotrophic lateral sclerosis (ALS) survival. ⋯ Higher concentrations of POPs in plasma are associated with reduced ALS survival, independent of age, gender, segment of onset and other covariates. This study helps characterise and quantify the combined effects of POPs on ALS and supports the concept that environmental exposures play a role in disease pathogenesis.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2019
Comparative StudyCSF neurogranin as a neuronal damage marker in CJD: a comparative study with AD.
To investigate whether cerebrospinal fluid (CSF) neurogranin concentrations are altered in sporadic Creutzfeldt-Jakob disease (CJD), comparatively with Alzheimer's disease (AD), and associated with neuronal degeneration in brain tissue. ⋯ Neurogranin is a new biomarker of prion pathogenesis with diagnostic and prognostic abilities, which reflects the degree of neuronal damage in brain tissue in a CJD subtype manner.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2019
Cannabis use is both independently associated with and mediates worse psychosocial health in patients with epilepsy.
To examine whether cannabis use is associated with or mediates psychosocial health in people with epilepsy. ⋯ There is a strong and independent association between cannabis use and poor psychosocial health, and it partially mediates the deleterious effect of a psychiatric history on these same outcomes. Inclusion of PROMs in future cannabis trials is warranted.