European journal of clinical investigation
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Eur. J. Clin. Invest. · Mar 2005
Multicenter StudyEradication of Helicobacter pylori increases platelet count in patients with idiopathic thrombocytopenic purpura in Japan.
The effect of Helicobacter pylori eradication on the platelet count in patients with thrombocytopenic purpura is controversial. In this multicentre study, we prospectively assessed the effect of H. pylori eradication therapy in idiopathic thrombocytopenic purpura patients. ⋯ Helicobacter pylori infection played a role in the pathogenesis of idiopathic thrombocytopenic purpura in approximately 30% of all patients assessed and 45% of the patients with H. pylori infection. Eradication of H. pylori in idiopathic thrombocytopenic purpura patients led to improved disease activity.