European journal of clinical investigation
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Eur. J. Clin. Invest. · Jun 2011
ReviewGenetics of type 2 diabetes: pathophysiologic and clinical relevance.
Recent genome-wide association studies enlarged our knowledge about the genetic background of type 2 diabetes. ⋯ Future studies need to target the issue of hidden heritability and to detect the causal gene variants within the identified gene loci. Improved understanding of the genetic contribution to type 2 diabetes may then help addressing the questions whether genotyping is useful to predict individual diabetes risk, identifies individual responsiveness to preventive and therapeutic interventions or at least allows for breaking down type 2 diabetes into smaller, clinically meaningful subtypes.